Predictors of germline genetic testing referral and completion in ovarian cancer patients at a Comprehensive Cancer Center.

ABSTRACT

OBJECTIVES: To identify predictors of referral and completion of germline genetic testing among newly diagnosed ovarian cancer patients, with a focus on geographic social deprivation, oncologist-level practices, and time between diagnosis and completion of testing. METHODS: Clinical and sociodemographic data were abstracted from medical records of patients newly diagnosed with ovarian cancer between 2014 and 2019 in the University of North Carolina Health System. Factors associated with referral for genetic counseling, completion of germline testing, and time between diagnosis and test results were identified using multivariable regression. RESULTS: 307/459 (67%) patients were referred for genetic counseling and 285/459 (62%) completed testing. The predicted probability of test completion was 0.83 (95% CI 0.77-0.88) for patients with a referral compared to 0.27 (95% CI 0.18-0.35) for patients without a referral. The predicted probability of referral was 0.75 (95% CI 0.69-0.82) for patients at the 25th percentile of ZIP code-level Social Deprivation Index (SDI) and 0.67 (0.60-0.74) for patients at the 75th percentile of SDI. Referral varied by oncologist, with predicted probabilities ranging from 0.47 (95% CI 0.32-0.62) to 0.93 (95% CI 0.85-1.00) across oncologists. The median time between diagnosis and test results was 137 days (IQR 55-248 days). This interval decreased by a predicted 24.46 days per year (95% CI 37.75-11.16). CONCLUSIONS: We report relatively high germline testing and a promising trend in time from diagnosis to results, with variation by oncologist and patient factors. Automated referral, remote genetic counseling and sample collection, reduced out-of-pocket costs, and educational interventions should be explored.