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Traumatic ulcerative granuloma with stromal eosinophilia mimicking a squamous cell carcinoma.
Bordignon, Natália-Cristina-Trentin; Correia-Neto, Ivan-José; Gondak, Rogério; de Albuquerque-Júnior, Ricardo-Luiz-Cavalcanti.
Afiliação
  • Bordignon NC; DDS, MSc, PhD. Department of Pathology, Federal University of Santa Catarina, Postgraduate Program in Dentistry, Florianópolis, Santa Catarina, Brazil.
  • Correia-Neto IJ; DDS, MSc, PhD student. Piracicaba Dental School, University of Campinas (UNICAMP), Postgraduate Program in Stomatopathology, Piracicaba, São Paulo, Brazil.
  • Gondak R; DDS, MSc, PhD. Department of Pathology, Federal University of Santa Catarina, Health Sciences Center, Florianópolis, Santa Catarina, Brazil.
  • de Albuquerque-Júnior RL; DDS, MSc, PhD. Department of Pathology, Federal University of Santa Catarina, Health Sciences Center, Florianópolis, Santa Catarina, Brazil.
J Clin Exp Dent ; 16(3): e377-e382, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38600925
ABSTRACT
Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a rare lesion of a traumatic-reactive nature of the oral mucosa that can clinically mimic an oral carcinoma. A 59-year-old male patient presented painful ulceration with indurated margins on the base of the tongue, extending to the floor of the mouth. The use of ill-fitting denture hurting the mucosa of the region was reported by the patient. The evolution time was 45 days. The presumptive diagnoses were oral squamous cell carcinoma and chronic ulcer. An incisional biopsy revealed an ulceration associated with an eosinophil-rich inflammatory infiltrate and a bed of proliferating histiocyte-like cells in either diffuse or fasciculate arrangement. There was diffuse immunopositivity for CD3, but focal for CD68 and α-SMA, and negativity for CD30. The final diagnosis was TUGSE. The use of the ill-fitting dental prosthesis was suspended and the lesion had complete spontaneous remission three weeks later. TUGSE is an uncommon traumatic self-limiting lesion that must be included in the differential diagnosis of ulcerative lesions resembling oral cancer. The correlation of clinical and histopathological findings is pivotal for a proper diagnosis, avoiding unnecessary aggressive surgical approaches. Key wordsOral ulcer, eosinophilia, immunohistochemical, differential diagnosis.

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article