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SARS-CoV-2-specific mucosal immune response in vaccinated versus infected children.
Conti, Maria Giulia; Piano Mortari, Eva; Nenna, Raffaella; Pierangeli, Alessandra; Sorrentino, Leonardo; Frasca, Federica; Petrarca, Laura; Mancino, Enrica; Di Mattia, Greta; Matera, Luigi; Fracella, Matteo; Albano, Christian; Scagnolari, Carolina; Capponi, Martina; Cinicola, Bianca; Carsetti, Rita; Midulla, Fabio.
Afiliação
  • Conti MG; Department of Maternal, Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
  • Piano Mortari E; B Cell Unit, Immunology Research Area, Bambino Gesù Children's Hospital, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Nenna R; Department of Maternal, Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
  • Pierangeli A; Laboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
  • Sorrentino L; Laboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
  • Frasca F; Laboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
  • Petrarca L; Department of Maternal, Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
  • Mancino E; Department of Maternal, Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
  • Di Mattia G; Department of Maternal, Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
  • Matera L; Department of Maternal, Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
  • Fracella M; Laboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
  • Albano C; B Cell Unit, Immunology Research Area, Bambino Gesù Children's Hospital, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Scagnolari C; Laboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
  • Capponi M; Department of Maternal, Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
  • Cinicola B; Department of Maternal, Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
  • Carsetti R; B Cell Unit, Immunology Research Area, Bambino Gesù Children's Hospital, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Midulla F; Department of Maternal, Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Front Cell Infect Microbiol ; 14: 1231697, 2024.
Article em En | MEDLINE | ID: mdl-38601739
ABSTRACT
The anti-COVID-19 intramuscular vaccination induces a strong systemic but a weak mucosal immune response in adults. Little is known about the mucosal immune response in children infected or vaccinated against SARS-CoV-2. We found that 28% of children had detectable salivary IgA against SARS-CoV-2 even before vaccination, suggesting that, in children, SARS-CoV-2 infection may be undiagnosed. After vaccination, only receptor-binding domain (RBD)-specific IgA1 significantly increased in the saliva. Conversely, infected children had significantly higher salivary RBD-IgA2 compared to IgA1, indicating that infection more than vaccination induces a specific mucosal immune response in children. Future efforts should focus on development of vaccine technologies that also activate mucosal immunity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunidade nas Mucosas / COVID-19 Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunidade nas Mucosas / COVID-19 Idioma: En Ano de publicação: 2024 Tipo de documento: Article