Mechanisms and implications of podocyte autophagy in chronic kidney disease.
Am J Physiol Renal Physiol
; 326(6): F877-F893, 2024 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-38601984
ABSTRACT
Autophagy is a protective mechanism through which cells degrade and recycle proteins and organelles to maintain cellular homeostasis and integrity. An accumulating body of evidence underscores the significant impact of dysregulated autophagy on podocyte injury in chronic kidney disease (CKD). In this review, we provide a comprehensive overview of the diverse types of autophagy and their regulation in cellular homeostasis, with a specific emphasis on podocytes. Furthermore, we discuss recent findings that focus on the functional role of different types of autophagy during podocyte injury in chronic kidney disease. The intricate interplay between different types of autophagy and podocyte health requires further research, which is critical for understanding the pathogenesis of CKD and developing targeted therapeutic interventions.
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Base de dados:
MEDLINE
Assunto principal:
Autofagia
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Podócitos
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Insuficiência Renal Crônica
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article