Ferulic acid nanoemulsion as a promising anti-ulcer tool: in vitro and in vivo assessment.
Drug Dev Ind Pharm
; 50(5): 460-469, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38602337
ABSTRACT
OBJECTIVE:
Ferulic acid (FA) is a promising nutraceutical molecule which exhibits antioxidant and anti-inflammatory properties, but it suffers from poor solubility and bioavailability. In the presented study, FA nanoemulsions were prepared to potentiate the therapeutic efficacy of FA in prevention of gastric ulcer.METHODS:
FA nanoemulsions were prepared, pharmaceutically characterized, and the selected nanoemusion was tested for its ulcer-ameliorative properties in rats after induction of gastric ulcer using ethanol, by examination of stomach tissues, assessment of serum IL-1ß and TNF-α, assessment of nitric oxide, prostaglandin E2, glutathione, catalase and thiobarbituric acid reactive substance in stomach homogenates, as well as histological and immunohistochemical evaluation.RESULTS:
Results revealed that the selected FA nanoemulsion showed a particle size of 90.43 nm, sustained release of FA for 8 h, and better in vitro anti-inflammatory properties than FA. Moreover, FA nanoemulsion exhibited significantly better anti-inflammatory and antioxidant properties in vivo, and the gastric tissue treated with FA nanoemulsion was comparable to the normal control upon histological and immunohistochemical evaluation.CONCLUSION:
Findings suggest that the prepared ferulic acid nanoemulsion is an ideal anti-ulcer system, which is worthy of further investigations.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Úlcera Gástrica
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Ácidos Cumáricos
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Emulsões
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Nanopartículas
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Antiulcerosos
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Antioxidantes
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article