The therapeutic potential of thiocyanate and hypothiocyanous acid against pulmonary infections.
Free Radic Biol Med
; 219: 104-111, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38608822
ABSTRACT
Hypothiocyanous acid (HOSCN) is an endogenous oxidant produced by peroxidase oxidation of thiocyanate (SCN-), an ubiquitous sulfur-containing pseudohalide synthesized from cyanide. HOSCN serves as a potent microbicidal agent against pathogenic bacteria, viruses, and fungi, functioning through thiol-targeting mechanisms, independent of currently approved antimicrobials. Additionally, SCN- reacts with hypochlorous acid (HOCl), a highly reactive oxidant produced by myeloperoxidase (MPO) at sites of inflammation, also producing HOSCN. This imparts both antioxidant and antimicrobial potential to SCN-. In this review, we discuss roles of HOSCN/SCN- in immunity and potential therapeutic implications for combating infections.
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Base de dados:
MEDLINE
Assunto principal:
Tiocianatos
/
Anti-Infecciosos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article