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Intolerance of uncertainty affects the behavioral and neural mechanisms of higher generalization.
Wu, Qi; Xu, Lei; Wan, Jiaming; Yu, Zhang; Lei, Yi.
Afiliação
  • Wu Q; Institute for Brain and Psychological Sciences, Sichuan Normal University, China.
  • Xu L; Institute for Brain and Psychological Sciences, Sichuan Normal University, China.
  • Wan J; Institute for Brain and Psychological Sciences, Sichuan Normal University, China.
  • Yu Z; Institute for Brain and Psychological Sciences, Sichuan Normal University, China.
  • Lei Y; Institute for Brain and Psychological Sciences, Sichuan Normal University, China.
Cereb Cortex ; 34(4)2024 Apr 01.
Article em En | MEDLINE | ID: mdl-38615238
ABSTRACT
Intolerance of uncertainty (IU) is associated with several anxiety disorders. In this study, we employed rewards and losses as unconditioned positive and negative stimuli, respectively, to explore the effects of an individual's IU level on positive and negative generalizations using magnetic resonance imaging technology. Following instrumental learning, 48 participants (24 high IU; 24 low IU) were invited to complete positive and negative generalization tasks; their behavioral responses and neural activities were recorded by functional magnetic resonance imaging. The behavior results demonstrated that participants with high IUs exhibited higher generalizations to both positive and negative cues as compared with participants having low IUs. Neuroimaging results demonstrated that they exhibited higher activation levels in the right anterior insula and the default mode network (i.e. precuneus and posterior cingulate gyrus), as well as related reward circuits (i.e. caudate and right putamen). Therefore, higher generalization scores and the related abnormal brain activation may be key markers of IU as a vulnerability factor for anxiety disorders.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ansiedade / Encéfalo Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ansiedade / Encéfalo Idioma: En Ano de publicação: 2024 Tipo de documento: Article