Elevation of circulating DNAs of disease-associated cytokines in serum cell-free DNA from patients with alopecia areata.
Biosci Trends
; 18(2): 198-200, 2024 Jun 06.
Article
em En
| MEDLINE
| ID: mdl-38616129
ABSTRACT
Alopecia areata (AA) is an autoimmune disease characterized by damage to hair follicles and hair loss. Cell-free DNA (cfDNA) has recently received attention as a biomarker of various disorders including inflammatory skin diseases. In this study, we aimed to investigate the clinical significance of cfDNA and the circulating DNAs of disease-associated cytokines in AA patients. Serum samples were obtained from 63 patients with AA and 32 healthy controls (HC). Using droplet digital polymerase chain reaction, circulating C-X-C motif chemokine ligand (CXCL) 9, CXCL10, CXCL11, C-X-C motif chemokine receptor 3, interferon (IFN)-γ, interleukin (IL) -7, IL-15, and Janus kinase (JAK) 2 were detectable in both HC and AA patients. Among the detectable DNAs, copies of circulating CXCL9, CXCL11, IL-15, IFN-γ, and JAK2 were significantly higher in AA patients than in HC. These results suggest that increased circulating DNA levels may reflect damage to hair follicles in AA patients.
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Base de dados:
MEDLINE
Assunto principal:
Citocinas
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Alopecia em Áreas
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Ácidos Nucleicos Livres
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article