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Photobiomodulation therapy in improvement of harmful neural plasticity in sodium salicylate-induced tinnitus.
Montazeri, Katayoon; Farhadi, Mohammad; Majdabadi, Abbas; Akbarnejad, Zainab; Fekrazad, Reza; Shahbazi, Ali; Mahmoudian, Saeid.
Afiliação
  • Montazeri K; The Five Senses Health Institute, ENT and Head and Neck Research Center, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
  • Farhadi M; The Five Senses Health Institute, ENT and Head and Neck Research Center, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
  • Majdabadi A; Dentistry Research Institute, Laser Research Center of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
  • Akbarnejad Z; The Five Senses Health Institute, ENT and Head and Neck Research Center, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
  • Fekrazad R; Radiation Sciences Research Center, Laser Research Center in Medical Sciences, AJA University of Medical Sciences, Tehran, Iran.
  • Shahbazi A; Faculty of Advanced Technologies in Medicine, Department of Neuroscience, Iran University of Medical Sciences (IUMS), Tehran, Iran.
  • Mahmoudian S; The Five Senses Health Institute, ENT and Head and Neck Research Center, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
PLoS One ; 19(4): e0296607, 2024.
Article em En | MEDLINE | ID: mdl-38626075
ABSTRACT
Tinnitus is a common annoying symptom without effective and accepted treatment. In this controlled experimental study, photobiomodulation therapy (PBMT), which uses light to modulate and repair target tissue, was used to treat sodium salicylate (SS)-induced tinnitus in a rat animal model. Here, PBMT was performed simultaneously on the peripheral and central regions involved in tinnitus. The results were evaluated using objective tests including gap pre-pulse inhibition of acoustic startle (GPIAS), auditory brainstem response (ABR) and immunohistochemistry (IHC). Harmful neural plasticity induced by tinnitus was detected by doublecortin (DCX) protein expression, a known marker of neural plasticity. PBMT parameters were 808 nm wavelength, 165 mW/cm2 power density, and 99 J/cm2 energy density. In the tinnitus group, the mean gap in noise (GIN) value of GPIAS test was significantly decreased indicated the occurrence of an additional perceived sound like tinnitus and also the mean ABR threshold and brainstem transmission time (BTT) were significantly increased. In addition, a significant increase in DCX expression in the dorsal cochlear nucleus (DCN), dentate gyrus (DG) and the parafloccular lobe (PFL) of cerebellum was observed in the tinnitus group. In PBMT group, a significant increase in the GIN value, a significant decrease in the ABR threshold and BTT, and also significant reduction of DCX expression in the DG were observed. Based on our findings, PBMT has the potential to be used in the management of SS-induced tinnitus.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Zumbido / Núcleo Coclear / Terapia com Luz de Baixa Intensidade Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Zumbido / Núcleo Coclear / Terapia com Luz de Baixa Intensidade Idioma: En Ano de publicação: 2024 Tipo de documento: Article