End-tidal carbon monoxide concentrations measured within 48 hours of birth predict hemolytic hyperbilirubinemia.
J Perinatol
; 44(6): 897-901, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38627593
ABSTRACT
OBJECTIVES:
To determine, among neonates at-risk for hyperbilirubinemia, whether measuring end-tidal carbon monoxide concentration (ETCOc) twice before 48 hours could identify those who would develop hyperbilirubinemia and differentiate hemolytic vs. non-hemolytic causes.METHODS:
Prospective study on neonates meeting criteria "at-risk for hyperbilirubinemia." Routine bilirubin measurements and 10-day follow-up were used to categorize neonates as; (1) normal (no hyperbilirubinemia, all bilirubins <95th percentile of Bhutani nomogram), (2) having hemolytic hyperbilirubinemia (bilirubin ≥95th percentile, DAT+, elevated retic, or G6PD+), or (3) having non-hemolytic hyperbilirubinemia.RESULTS:
386 neonates were enrolled. 321 (83%) did not develop hyperbilirubinemia and 65 (17%) did, of which 29 were judged hemolytic and 36 non-hemolytic. High ETCOc differentiated the hemolytic group (p < 0.001). First-day ETCOc correlated with bilirubin and with reticulocyte count (r = 0.896 and 0.878) and sensitivity and specificity for predicting hyperbilirubinemia were excellent (83% and 95%).CONCLUSIONS:
ETCO measurement in the first 48 hours after birth predicts hemolytic hyperbilirubinemia.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bilirrubina
/
Monóxido de Carbono
/
Hiperbilirrubinemia Neonatal
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article