Emerging paradigms in cancer cell plasticity.
BMB Rep
; 57(6): 273-280, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38627950
ABSTRACT
Cancer cells metastasize to distant organs by altering their characteristics within the tumor microenvironment (TME) to effectively overcome challenges during the multistep tumorigenesis. Plasticity endows cancer cell with the capacity to shift between different morphological states to invade, disseminate, and seed metastasis. The epithelial-to-mesenchymal transition (EMT) is a theory derived from tissue biopsy, which explains the acquisition of EMT transcription factors (TFs) that convey mesenchymal features during cancer migration and invasion. On the other hand, adherent-to-suspension transition (AST) is an emerging theory derived from liquid biopsy, which describes the acquisition of hematopoietic features by AST-TFs that reprograms anchorage dependency during the dissemination of circulating tumor cells (CTCs). The induction and plasticity of EMT and AST dynamically reprogram cell-cell interaction and cell-matrix interaction during cancer dissemination and colonization. Here, we review the mechanisms governing cellular plasticity of AST and EMT during the metastatic cascade and discuss therapeutic challenges posed by these two morphological adaptations to provide insights for establishing new therapeutic interventions. [BMB Reports 2024; 57(6) 273-280].
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transição Epitelial-Mesenquimal
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Microambiente Tumoral
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Plasticidade Celular
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Neoplasias
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article