Antibacterial activity of corydalis saxicola bunting total alkaloids against Porphyromonas gingivalis in vitro.
Future Microbiol
; 19(7): 595-606, 2024.
Article
em En
| MEDLINE
| ID: mdl-38629885
ABSTRACT
Aim:
To investigate the antibacterial effects of Corydalis Saxicola bunting total alkaloid (CSBTA) on Porphyromonas gingivalis.Methods:
SEM, chemical staining, RT-qPCR and ELISA were used to detect effects of CSBTA on P. gingivalis.Results:
CSBTA treatment caused shrinkage and rupture of P. gingivalis morphology, decreased biofilm density and live bacteria in biofilm, as well as reduced mRNA expression of virulence genes hagA, hagB, kgp, rgpA and rgpB of P. gingivalis. Furthermore, NOK cells induced by CSBTA-treated P. gingivalis exhibited lower IL-6 and TNF-α expression levels.Conclusion:
CSBTA is able to kill free P. gingivalis, disrupt the biofilm and weaken the pathogenicity of P. gingivalis. It has the potential to be developed as a drug against P. gingivalis infection.
[Box see text].
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Porphyromonas gingivalis
/
Biofilmes
/
Corydalis
/
Alcaloides
/
Antibacterianos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article