The role of thymic stromal lymphopoietin in cutaneous disorders.
Arch Dermatol Res
; 316(5): 123, 2024 Apr 17.
Article
em En
| MEDLINE
| ID: mdl-38630260
ABSTRACT
Thymic Stromal Lymphopoietin (TSLP) is an important cytokine that invokes early immune responses. TSLP, an IL-7-like cytokine encoded by the TSLP gene, activates JAK1 and JAK2 signaling pathways, stimulating dendritic cells to induce inflammatory Th2 cells. This cytokine is associated with pruritus in various cutaneous disorders, particularly atopic dermatitis. Varying levels of the cytokine TSLP have been demonstrated in studies of different cutaneous disorders. Pharmacological treatment targeting TSLP has been explored recently, particularly in the realm of atopic dermatitis.This review explores the relation of TSLP to cutaneous diseases, highlighting its potential as a biomarker for monitoring disease progression in discoid lupus erythematosus (DLE). The pharmacological therapy involving TSLP is discussed, along with the potential role of TSLP promotion in the treatment of alopecia areata. This overview examines the background, structure, and functions of TSLP, with a focus on its association with cutaneous disorders and a special focus on the impact of the atopic march.
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Base de dados:
MEDLINE
Assunto principal:
Dermatopatias
/
Linfopoietina do Estroma do Timo
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article