Illuminating the complete ß-cell mass of the human pancreas- signifying a new view on the islets of Langerhans.
Nat Commun
; 15(1): 3318, 2024 Apr 18.
Article
em En
| MEDLINE
| ID: mdl-38632302
ABSTRACT
Pancreatic islets of Langerhans play a pivotal role in regulating blood glucose homeostasis, but critical information regarding their mass, distribution and composition is lacking within a whole organ context. Here, we apply a 3D imaging pipeline to generate a complete account of the insulin-producing islets throughout the human pancreas at a microscopic resolution and within a maintained spatial 3D context. These data show that human islets are far more heterogenous than previously accounted for with regards to their size distribution and cellular make up. By deep tissue 3D imaging, this in-depth study demonstrates that 50% of the human insulin-expressing islets are virtually devoid of glucagon-producing α-cells, an observation with significant implications for both experimental and clinical research.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ilhotas Pancreáticas
/
Células Secretoras de Glucagon
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article