HLA-DRB1 is associated with cefaclor-induced immediate hypersensitivity.
World Allergy Organ J
; 17(5): 100901, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38638799
ABSTRACT
Background:
Drug-induced hypersensitivity such as anaphylaxis is an important cause of drug-related morbidity and mortality. Cefaclor is a leading cause of drug induced type I hypersensitivity in Korea, but little is yet known about genetic biomarkers to predict this hypersensitivity reaction. We aimed to evaluate the possible involvement of genes in cefaclor induced type I hypersensitivity.Methods:
Whole exome sequencing (WES) and HLA genotyping were performed in 43 patients with cefaclor induced type I hypersensitivity. In addition, homology modeling was performed to identify the binding forms of cefaclor to HLA site.Results:
Anaphylaxis was the most common phenotype of cefaclor hypersensitivity (90.69%). WES results show that rs62242177 and rs62242178 located in LIMD1 region were genome-wide significant at the 5 × 10-8 significance level. Cefaclor induced type I hypersensitivity was significantly associated with HLA-DRB1∗0403 (OR 4.61 [95% CI 1.51-14.09], P < 0.002) and HLA-DRB1∗1454 (OR 3.86 [95% CI 1.09-13.67], P < 0.002).Conclusion:
LIMD1, HLA-DRB1∗0403 and HLA-DRB1∗1454 may affect susceptibility to cefaclor induced type I hypersensitivity. Further confirmative studies with a larger patient population should be performed to ascertain the role of HLA-DRB1 and LIMD1 in the development of cefaclor induced hypersensitivity.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article