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A review of biomacromolecule-based 3D bioprinting strategies for structure-function integrated repair of skin tissues.
Liu, Hao; Xing, Fei; Yu, Peiyun; Zhe, Man; Duan, Xin; Liu, Ming; Xiang, Zhou; Ritz, Ulrike.
Afiliação
  • Liu H; Department of Orthopedic Surgery, Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
  • Xing F; Department of Pediatric Surgery, Orthopedic Research Institute, West China Hospital, Sichuan University, 610041 Chengdu, China.
  • Yu P; LIMES Institute, Department of Molecular Brain Physiology and Behavior, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.
  • Zhe M; Animal Experiment Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Duan X; Department of Orthopedic Surgery, Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
  • Liu M; Department of Orthopedic Surgery, Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
  • Xiang Z; Department of Orthopedic Surgery, Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China; Department of Orthopedics, Sanya People's Hospital, 572000 Sanya, Hainan, China. Electronic ad
  • Ritz U; Department of Orthopaedics and Traumatology, Biomatics Group, University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, 55131 Mainz, Germany. Electronic address: ritz@uni-mainz.de.
Int J Biol Macromol ; 268(Pt 2): 131623, 2024 May.
Article em En | MEDLINE | ID: mdl-38642687
ABSTRACT
When skin is damaged or affected by diseases, it often undergoes irreversible scar formation, leading to aesthetic concerns and psychological distress for patients. In cases of extensive skin defects, the patient's life can be severely compromised. In recent years, 3D printing technology has emerged as a groundbreaking approach to skin tissue engineering, offering promising solutions to various skin-related conditions. 3D bioprinting technology enables the precise fabrication of structures by programming the spatial arrangement of cells within the skin tissue and subsequently printing skin replacements either in a 3D bioprinter or directly at the site of the defect. This study provides a comprehensive overview of various biopolymer-based inks, with a particular emphasis on chitosan (CS), starch, alginate, agarose, cellulose, and fibronectin, all of which are natural polymers belonging to the category of biomacromolecules. Additionally, it summarizes artificially synthesized polymers capable of enhancing the performance of these biomacromolecule-based bioinks, thereby composing hybrid biopolymer inks aimed at better application in skin tissue engineering endeavors. This review paper examines the recent advancements, characteristics, benefits, and limitations of biological 3D bioprinting techniques for skin tissue engineering. By utilizing bioinks containing seed cells, hydrogels with bioactive factors, and biomaterials, complex structures resembling natural skin can be accurately fabricated in a layer-by-layer manner. The importance of biological scaffolds in promoting skin wound healing and the role of 3D bioprinting in skin tissue regeneration processes is discussed. Additionally, this paper addresses the challenges and constraints associated with current 3D bioprinting technologies for skin tissue and presents future perspectives. These include advancements in bioink formulations, full-thickness skin bioprinting, vascularization strategies, and skin appendages bioprinting.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pele / Engenharia Tecidual / Bioimpressão / Impressão Tridimensional Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pele / Engenharia Tecidual / Bioimpressão / Impressão Tridimensional Idioma: En Ano de publicação: 2024 Tipo de documento: Article