[Advances in Research on Cell Metabolic Interactions in the Tumor Microenvironment]. / è¿ç¤å¾®ç¯å¢ä¸ç»è代谢ç¸äºä½ç¨çç 究è¿å±.
Sichuan Da Xue Xue Bao Yi Xue Ban
; 55(2): 482-489, 2024 Mar 20.
Article
em Zh
| MEDLINE
| ID: mdl-38645846
ABSTRACT
Metabolic reprogramming plays a critical role in tumorigenesis and tumor progression. The metabolism and the proliferation of tumors are regulated by both intrinsic factors within the tumor and the availability of metabolites in the tumor microenvironment (TME). The metabolic niche within the TME is primarily orchestrated at 3 levels 1) the regulation of tumor metabolism by factors intrinsic to the tumors, 2) the interaction between tumor cells and T cells, macrophages, and stromal cells, and 3) the metabolic heterogeneity of tumor cells within the tissue space. Herein, we provided a concise overview of the various metabolic regulatory modes observed in tumor cells. Additionally, we extensively analyzed the interaction between tumor cells and other cells within the TME, as well as the metabolic characteristics and functions of different types of cells. Ultimately, this review provides a theoretical basis and novel insights for the precision treatment of tumors.
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Base de dados:
MEDLINE
Assunto principal:
Microambiente Tumoral
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Neoplasias
Idioma:
Zh
Ano de publicação:
2024
Tipo de documento:
Article