Significant response to pembrolizumab plus lenvatinib in Epstein-Barr-virus-associated intrahepatic cholangiocarcinoma: a case report.
Cancer Biol Ther
; 25(1): 2338644, 2024 Dec 31.
Article
em En
| MEDLINE
| ID: mdl-38650446
ABSTRACT
BACKGROUND:
The prognosis for advanced intrahepatic cholangiocarcinoma (iCCA) is poor, and there remains an urgent need to develop efficient systemic therapy. The efficacy of Pembrolizumab immunotherapy combined with lenvatinibin in iCCA is still unclear. The role of Epstein-Barr-virus (EBV) as a biomarker in iCCA for response to immunotherapy needs further exploration. CASE PRESENTATION We report a case of a 60-year-old female with EBV-associated advanced iCCA (EBVaiCCA) who progressed after first-line therapy. She accomplished an available response to the combination therapy of pembrolizumab with lenvatinib, with overall survival of 20 months.CONCLUSIONS:
As far as we know, this is the first case report about the application of Pembrolizumab with lenvatinib for EBVaiCCA patients. This case indicates that the combination of immunotherapy and antiangiogenic therapy provides a glimmer of hope for advanced EBVaiCCA patients.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Compostos de Fenilureia
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Quinolinas
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Protocolos de Quimioterapia Combinada Antineoplásica
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Colangiocarcinoma
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Infecções por Vírus Epstein-Barr
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Anticorpos Monoclonais Humanizados
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article