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Comparison of Flow Reduction Efficacy of Nominal and Oversized Flow Diverters Using a Novel Measurement-assisted in Silico Method.
Csippa, Benjamin; Sándor, Levente; Závodszky, Gábor; Szikora, István; Paál, György.
Afiliação
  • Csippa B; Department of Hydrodynamic Systems, Faculty of Mechanical Engineering,, Budapest University of Technology and Economics, Muegyetem rkp 1-3, 1111, Budapest, Hungary. bcsippa@hds.bme.hu.
  • Sándor L; Department of Hydrodynamic Systems, Faculty of Mechanical Engineering,, Budapest University of Technology and Economics, Muegyetem rkp 1-3, 1111, Budapest, Hungary.
  • Závodszky G; Department of Hydrodynamic Systems, Faculty of Mechanical Engineering,, Budapest University of Technology and Economics, Muegyetem rkp 1-3, 1111, Budapest, Hungary.
  • Szikora I; Faculty of Science, Informatics Institute, Computational Science Lab, University of Amsterdam, Amsterdam, The Netherlands.
  • Paál G; National Institute of Mental Health, Neurology, and Neurosurgery, Department of Neurointerventions, Budapest, Hungary.
Clin Neuroradiol ; 2024 Apr 23.
Article em En | MEDLINE | ID: mdl-38652163
ABSTRACT

PURPOSE:

The high efficacy of flow diverters (FD) in the case of wide-neck aneurysms is well demonstrated, yet new challenges have arisen because of reported posttreatment failures and the growing number of new generation of devices. Our aim is to present a measurement-supported in silico workflow that automates the virtual deployment and subsequent hemodynamic analysis of FDs. In this work, the objective is to analyze the effects of FD deployment variability of two manufacturers on posttreatment flow reduction.

METHODS:

The virtual deployment procedure is based on detailed mechanical calibration of the flow diverters, while the flow representation is based on hydrodynamic resistance (HR) measurements. Computational fluid dynamic simulations resulted in 5 untreated and 80 virtually treated scenarios, including 2 FD designs in nominal and oversized deployment states. The simulated aneurysmal velocity reduction (AMVR) is correlated with the HR values and deployment scenarios.

RESULTS:

The linear HR coefficient and AMVR revealed a power-law relationship considering all 80 deployments. In nominal deployment scenarios, a significantly larger average AMVR was obtained (60.3%) for the 64-wire FDs than for 48-wire FDs (51.9%). In oversized deployments, the average AMVR was almost the same for 64-wire and 48-wire device types, 27.5% and 25.7%, respectively.

CONCLUSION:

The applicability of our numerical workflow was demonstrated, also in large-scale hemodynamic investigations. The study revealed a robust power-law relationship between a HR coefficient and AMVR. Furthermore, the 64 wire configurations in nominal sizing produced a significantly higher posttreatment flow reduction, replicating the results of other in vitro studies.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article