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New eremophilane-type sesquiterpenes from Synotis solidaginea.
Wei, Xin-Yi; Sun, Hong-Bing; Xi, Rui-Ying; Wu, Fan; Liu, Yi-Lin; Jin, Zhuo-Lin; Guo, Da-Le; Xia, Bing; Wang, Fei; Zhou, Yan.
Afiliação
  • Wei XY; Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, PR China; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China; University of Chinese Academy of Sciences, Beijing 101408, PR China.
  • Sun HB; Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, PR China; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China; University of Chinese Academy of Sciences, Beijing 101408, PR China; Sichuan Academy of Chinese Medicine Sciences, Cheng
  • Xi RY; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China; University of Chinese Academy of Sciences, Beijing 101408, PR China.
  • Wu F; Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, PR China; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China; University of Chinese Academy of Sciences, Beijing 101408, PR China.
  • Liu YL; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China; University of Chinese Academy of Sciences, Beijing 101408, PR China.
  • Jin ZL; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China; University of Chinese Academy of Sciences, Beijing 101408, PR China.
  • Guo DL; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China.
  • Xia B; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China.
  • Wang F; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China.
  • Zhou Y; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China. Electronic address: zhouyan@cib.ac.cn.
Fitoterapia ; 175: 105970, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38653340
ABSTRACT
Eleven new highly oxygenated eremophilane-type sesquiterpenoids were isolated from the whole plant of Synotis solidaginea, including two pairs of C-8 S/R epimers. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis and the absolute configurations of 1 and 9 were confirmed by single-crystal X-ray crystallography using Cu Kα radiation. All the isolates were tested for the inhibition of LPS-stimulated NO production in macrophage-like mouse monocytic leukemia RAW264.7 cells. Compound 1 exhibited weak inhibitory effects with an IC50 of 71.2 µM.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Compostos Fitoquímicos / Óxido Nítrico Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Compostos Fitoquímicos / Óxido Nítrico Idioma: En Ano de publicação: 2024 Tipo de documento: Article