The role of vitamin D in outcomes of critical care in COVID-19 patients: evidence from an umbrella meta-analysis of interventional and observational studies.
Public Health Nutr
; 27(1): e127, 2024 Apr 24.
Article
em En
| MEDLINE
| ID: mdl-38654693
ABSTRACT
OBJECTIVES:
Several meta-analyses have suggested the beneficial effect of vitamin D on patients infected with severe acute respiratory syndrome coronavirus-2. This umbrella meta-analysis aims to evaluate influence of vitamin D supplementation on clinical outcomes and the mortality rate of COVID-19 patients.DESIGN:
Present study was designed as an umbrella meta-analysis. The following international databases were systematically searched till March 2023 Web of Science, PubMed, Scopus, and Embase. SETTINGS Random-effects model was employed to perform meta-analysis. Using AMSTAR critical evaluation tools, the methodological quality of the included meta-analyses was evaluated.PARTICIPANTS:
Adult patients suffering from COVID-19 were studied.RESULTS:
Overall, 13 meta-analyses summarising data from 4 randomised controlled trial and 9 observational studies were identified in this umbrella review. Our findings revealed that vitamin D supplementation and status significantly reduced mortality of COVID-19 [Interventional studies (ES = 0·42; 95 % CI 0·10, 0·75, P < 0·001; I2 = 20·4 %, P = 0·285) and observational studies (ES = 1·99; 95 % CI 1·37, 2·62, P < 0·001; I2 = 00·0 %, P = 0·944). Also, vitamin D deficiency increased the risk of infection and disease severity among patients.CONCLUSION:
Overall, vitamin D status is a critical factor influencing the mortality rate, disease severity, admission to intensive care unit and being detached from mechanical ventilation. It is vital to monitor the vitamin D status in all patients with critical conditions including COVID patients.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Vitamina D
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Suplementos Nutricionais
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Cuidados Críticos
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Estudos Observacionais como Assunto
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SARS-CoV-2
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COVID-19
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article