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Curcumin alleviates zearalenone-induced liver injury in mice by scavenging reactive oxygen species and inhibiting mitochondrial apoptosis pathway.
Yang, Xiaopeng; Zheng, Hao; Niu, Junlong; Chen, Xiaoshuang; Li, Hongfei; Rao, Zhiyong; Guo, Yongpeng; Zhang, Wei; Wang, Zhixiang.
Afiliação
  • Yang X; Animal Nutrition Control Laboratory of Henan Agricultural University, China.
  • Zheng H; Animal Nutrition Control Laboratory of Henan Agricultural University, China.
  • Niu J; Animal Nutrition Control Laboratory of Henan Agricultural University, China.
  • Chen X; Animal Nutrition Control Laboratory of Henan Agricultural University, China.
  • Li H; Animal Nutrition Control Laboratory of Henan Agricultural University, China.
  • Rao Z; Animal Nutrition Control Laboratory of Henan Agricultural University, China.
  • Guo Y; Animal Nutrition Control Laboratory of Henan Agricultural University, China.
  • Zhang W; Animal Nutrition Control Laboratory of Henan Agricultural University, China. Electronic address: weizhang@henau.edu.cn.
  • Wang Z; Animal Nutrition Control Laboratory of Henan Agricultural University, China. Electronic address: wzxhau@aliyun.com.
Ecotoxicol Environ Saf ; 277: 116343, 2024 Jun 01.
Article em En | MEDLINE | ID: mdl-38657456
ABSTRACT
Curcumin (CUR) is a compound extracted from turmeric that has a variety of functions including antioxidant and anti-inflammatory. As an estrogen-like mycotoxin, zearalenone (ZEN) not only attacks the reproductive system, but also has toxic effects on the liver. However, whether CUR can alleviate ZEN-induced liver injury remains unclear. This paper aims to investigate the protective effect of CUR against ZEN-induced liver injury in mice and explore the molecular mechanism involved. BALB/c mice were randomly divided into control (CON) group, CUR group (200 mg/kg b. w. CUR), ZEN group (40 mg/kg b. w. ZEN) and CUR+ZEN group (200 mg/kg b. w. CUR+40 mg/kg b. w. ZEN). 28 d after ZEN exposure and CUR treatment, blood and liver samples were collected for subsequent testing. The results showed that CUR reversed ZEN-induced hepatocyte swelling and necrosis in mice. It significantly reduced the serum alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in mice (p < 0.05). In addition, CUR significantly reduced hepatic ROS, malondialdehyde, hydrogen peroxide and apoptosis levels in mice (p < 0.05). Quantitative RT-PCR and Western blot results showed that CUR significantly reduced the expression of Bax and Caspase3, and reversed the increase of Nrf2, HO-1 and NQO1 expression in the liver of mice induced by ZEN (p < 0.05). In conclusion, CUR alleviated ZEN-induced liver injury in mice by scavenging ROS and inhibiting the mitochondrial apoptotic pathway.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Zearalenona / Espécies Reativas de Oxigênio / Apoptose / Curcumina / Doença Hepática Induzida por Substâncias e Drogas / Camundongos Endogâmicos BALB C Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Zearalenona / Espécies Reativas de Oxigênio / Apoptose / Curcumina / Doença Hepática Induzida por Substâncias e Drogas / Camundongos Endogâmicos BALB C Idioma: En Ano de publicação: 2024 Tipo de documento: Article