Sex Differences in the Association Between Depression and Incident Cardiovascular Disease.
JACC Asia
; 4(4): 279-288, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38660110
ABSTRACT
Background:
Depression is a known risk factor for cardiovascular disease (CVD), but the potential sex differences in this association remain unclear.Objectives:
The aim of this study was to investigate the association between depression and subsequent CVD events, and to explore potential sex differences.Methods:
The authors conducted a retrospective analysis using the JMDC Claims Database between 2005 and 2022. The study population included 4,125,720 individuals aged 18 to 75 years without a history of cardiovascular disease or renal failure and missing data at baseline. Participants were followed up for a mean of 1,288 days to assess the association between depression and subsequent CVD events, such as myocardial infarction, angina pectoris, stroke, heart failure, and atrial fibrillation.Results:
Our analysis revealed a significant association between depression and subsequent composite CVD events in both men and women, with a stronger association observed in women. The HR for the composite endpoint was 1.64 (95% CI 1.59-1.70) in women and 1.39 (95% CI 1.35-1.42) in men after multivariable adjustment (P for interaction <0.001). Furthermore, the individual components of the composite endpoint were also associated with depression in both men and women, each of which was also observed to be more strongly associated in women.Conclusions:
Our study provides evidence of a significant association between depression and subsequent CVD events in both men and women, with a more pronounced association observed in women. These findings highlight the importance of addressing depression and tailoring prevention and management strategies according to sex-specific factors.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article