Precursor-Directed Biosynthesis of Neoantimycin Derivatives with Selective Cytotoxicity.
J Nat Prod
; 87(5): 1376-1383, 2024 May 24.
Article
em En
| MEDLINE
| ID: mdl-38662398
ABSTRACT
A precursor-directed biosynthesis approach led to the accumulation of seven new neoantimycin derivatives (1-7) from Streptomyces conglobatus RJ2. Structure elucidation was conducted using NMR and HRESIMS analysis, and the absolute configuration was determined by advanced Marfey's method, Mosher's analysis, and ECD analysis. The obtained compounds revealed selective and significant cytotoxicity, specifically against colorectal cancer cells bearing the K-ras mutation, with IC50 values ranging from 40 nM to 3.5 µM.
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Base de dados:
MEDLINE
Assunto principal:
Streptomyces
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article