Cross-species spill-over potential of the H9N2 bat influenza A virus.
Nat Commun
; 15(1): 3449, 2024 Apr 25.
Article
em En
| MEDLINE
| ID: mdl-38664384
ABSTRACT
In 2017, a novel influenza A virus (IAV) was isolated from an Egyptian fruit bat. In contrast to other bat influenza viruses, the virus was related to avian A(H9N2) viruses and was probably the result of a bird-to-bat transmission event. To determine the cross-species spill-over potential, we biologically characterize features of A/bat/Egypt/381OP/2017(H9N2). The virus has a pH inactivation profile and neuraminidase activity similar to those of human-adapted IAVs. Despite the virus having an avian virus-like preference for α2,3 sialic acid receptors, it is unable to replicate in male mallard ducks; however, it readily infects ex-vivo human respiratory cell cultures and replicates in the lungs of female mice. A/bat/Egypt/381OP/2017 replicates in the upper respiratory tract of experimentally-infected male ferrets featuring direct-contact and airborne transmission. These data suggest that the bat A(H9N2) virus has features associated with increased risk to humans without a shift to a preference for α2,6 sialic acid receptors.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quirópteros
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Infecções por Orthomyxoviridae
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Receptores de Superfície Celular
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Patos
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Vírus da Influenza A Subtipo H9N2
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Furões
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article