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Bioinformatic Prohormone Discovery in Basal Metazoans: Insights from Trichoplax.
Nikitin, Mikhail A; Romanova, Daria Y; Moroz, Leonid L.
Afiliação
  • Nikitin MA; Belozersky Institute for Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation.
  • Romanova DY; Kharkevich Institute for Information Transmission Problems, RAS, Moscow, Russian Federation.
  • Moroz LL; Institute of Higher Nervous Activity and Neurophysiology of RAS, Moscow, Russian Federation.
Methods Mol Biol ; 2757: 531-581, 2024.
Article em En | MEDLINE | ID: mdl-38668982
ABSTRACT
Experimental discovery of neuropeptides and peptide hormones is a long and tedious task. Mining the genomic and transcriptomic sequence data with robust secretory peptide prediction tools can significantly facilitate subsequent experiments. We describe the application of various in silico neuropeptide discovery methods for the placozoan Trichopax adhaerens as an illustrated example and a powerful experimental paradigm for cellular and evolutionary biology. In total, 33 placozoan (neuro)peptide-like hormone precursors were found using homology-based BLAST search and repeat-based and comparative evolutionary methods. Some of the discovered precursors are homologous to insulins and RFamide precursors from Cnidaria and other animal phyla.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neuropeptídeos / Biologia Computacional / Placozoa Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neuropeptídeos / Biologia Computacional / Placozoa Idioma: En Ano de publicação: 2024 Tipo de documento: Article