Impact of magnetic resonance imaging-derived skeletal muscle index in locoregionally advanced nasopharyngeal carcinoma.
Eur Arch Otorhinolaryngol
; 281(7): 3707-3715, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38671169
ABSTRACT
PURPOSE:
To evaluate the clinical implication of magnetic resonance imaging (MRI)-derived skeletal muscle index (SMI) in locoregionally advanced nasopharyngeal carcinoma (LANPC) patients undergoing induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CCRT) and further to develop a nomogram for predicting survival prognosis.METHODS:
SMI was determined through baseline MRI at the third cervical level. The nomogram was based on a training cohort involving 409 LANPC patients. We validated the prognostic accuracy of this prognostic model in an internal validation cohort (n = 204) and an external independent cohort (n = 272).RESULTS:
SMI was an independent risk factor for OS. A prognostic model comprising age, TNM stage and SMI for individual survival prediction was developed and graphically represented as a nomogram. The model showed favorable discrimination (C-index 0.686), predictive accuracy [time dependent area under the curve (tAUC) at 5 years 0.70], and calibration, and was further validated in the internal and external validation datasets. A risk stratification derived from the model stratified these patients into three prognostic subgroups with significantly different survival.CONCLUSIONS:
Low SMI accessed by MRI was significantly associated with poor overall survival in LANPC patients undergoing IC + CCRT. Moreover, we established and validated a novel nomogram involving age, TNM stage and SMI that could provide accurate prognostic stratification among this population.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
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Neoplasias Nasofaríngeas
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Músculo Esquelético
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Nomogramas
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Carcinoma Nasofaríngeo
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Estadiamento de Neoplasias
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article