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HtpG-A Major Virulence Factor and a Promising Vaccine Antigen against Mycobacterium tuberculosis.
Berisio, Rita; Barra, Giovanni; Napolitano, Valeria; Privitera, Mario; Romano, Maria; Squeglia, Flavia; Ruggiero, Alessia.
Afiliação
  • Berisio R; Institute of Biostructures and Bioimaging, IBB, CNR, Via Pietro Castellino 111, I-80131 Naples, Italy.
  • Barra G; Institute of Biostructures and Bioimaging, IBB, CNR, Via Pietro Castellino 111, I-80131 Naples, Italy.
  • Napolitano V; Institute of Biostructures and Bioimaging, IBB, CNR, Via Pietro Castellino 111, I-80131 Naples, Italy.
  • Privitera M; Institute of Biostructures and Bioimaging, IBB, CNR, Via Pietro Castellino 111, I-80131 Naples, Italy.
  • Romano M; Institute of Biostructures and Bioimaging, IBB, CNR, Via Pietro Castellino 111, I-80131 Naples, Italy.
  • Squeglia F; Institute of Biostructures and Bioimaging, IBB, CNR, Via Pietro Castellino 111, I-80131 Naples, Italy.
  • Ruggiero A; Institute of Biostructures and Bioimaging, IBB, CNR, Via Pietro Castellino 111, I-80131 Naples, Italy.
Biomolecules ; 14(4)2024 Apr 11.
Article em En | MEDLINE | ID: mdl-38672487
ABSTRACT
Tuberculosis (TB) is the leading global cause of death f rom an infectious bacterial agent. Therefore, limiting its epidemic spread is a pressing global health priority. The chaperone-like protein HtpG of M. tuberculosis (Mtb) is a large dimeric and multi-domain protein with a key role in Mtb pathogenesis and promising antigenic properties. This dual role, likely associated with the ability of Heat Shock proteins to act both intra- and extra-cellularly, makes HtpG highly exploitable both for drug and vaccine development. This review aims to gather the latest updates in HtpG structure and biological function, with HtpG operating in conjunction with a large number of chaperone molecules of Mtb. Altogether, these molecules help Mtb recovery after exposure to host-like stress by assisting the whole path of protein folding rescue, from the solubilisation of aggregated proteins to their refolding. Also, we highlight the role of structural biology in the development of safer and more effective subunit antigens. The larger availability of structural information on Mtb antigens and a better understanding of the host immune response to TB infection will aid the acceleration of TB vaccine development.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Fatores de Virulência / Vacinas contra a Tuberculose / Mycobacterium tuberculosis / Antígenos de Bactérias Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Fatores de Virulência / Vacinas contra a Tuberculose / Mycobacterium tuberculosis / Antígenos de Bactérias Idioma: En Ano de publicação: 2024 Tipo de documento: Article