Diagnostic value of LGE and T1 mapping in multiple myeloma patients'heart.
BMC Cardiovasc Disord
; 24(1): 230, 2024 Apr 27.
Article
em En
| MEDLINE
| ID: mdl-38678215
ABSTRACT
BACKGROUND:
Unidentified heart failure occurs in patients with multiple myeloma when their heart was involved. CMR with late gadolinium enhancement (LGE) and T1 mapping can identify myocardial amyloid infiltrations.PURPOSE:
To explore the role of CMR with late gadolinium enhancement (LGE) and T1 mapping for detection of multiple myeloma patients'heart. MATERIAL ANDMETHODS:
A total of 16 MM patients with above underwent CMR (3.0-T) with T1 mapping (pre-contrast and post-contrast) and LGE imaging. In addition, 26 patients with non-obstructive hypertrophic cardiomyopathy and 26 healthy volunteers were compared to age- and sex-matched healthy controls without a history of cardiac disease, diabetes mellitus, or normal in CMR. All statistical analyses were performed using the statistical software GraphPad Prism. The measurement data were represented by median (X) and single sample T test was adopted. Enumeration data were represented by examples and Chi-tested was adopted. All tests were two-sided, and P values < 0.05 were considered statistically significant.RESULTS:
In MM group, LVEF was lower than healthy controls and higher than that of non-obstructive hypertrophic cardiomyopathy group, but without statistically significant difference (% 49.1 ± 17.5 vs. 55.6 ± 10.3, 40.4 ± 15.6, all P > 0.05). Pre-contrast T1 values of MM group were obviously higher than those of healthy controls and non-obstructive hypertrophic cardiomyopathy group (ms1462.0 ± 71.3vs. 1269.3 ± 42.3, 1324.0 ± 45.1, all P < 0.05). 16 cases (100%) in MM group all had LGE.CONCLUSION:
LGE joint T1 mapping wider clinical use techniques and follow-up the patients'disease severity.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Volume Sistólico
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Cardiomiopatia Hipertrófica
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Valor Preditivo dos Testes
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Função Ventricular Esquerda
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Imagem Cinética por Ressonância Magnética
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Meios de Contraste
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Mieloma Múltiplo
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article