MassDash: A Web-Based Dashboard for Data-Independent Acquisition Mass Spectrometry Visualization.
J Proteome Res
; 23(6): 2306-2314, 2024 Jun 07.
Article
em En
| MEDLINE
| ID: mdl-38684072
ABSTRACT
With the increased usage and diversity of methods and instruments being applied to analyze Data-Independent Acquisition (DIA) data, visualization is becoming increasingly important to validate automated software results. Here we present MassDash, a cross-platform DIA mass spectrometry visualization and validation software for comparing features and results across popular tools. MassDash provides a web-based interface and Python package for interactive feature visualizations and summary report plots across multiple automated DIA feature detection tools, including OpenSwath, DIA-NN, and dreamDIA. Furthermore, MassDash processes peptides on the fly, enabling interactive visualization of peptides across dozens of runs simultaneously on a personal computer. MassDash supports various multidimensional visualizations across retention time, ion mobility, m/z, and intensity, providing additional insights into the data. The modular framework is easily extendable, enabling rapid algorithm development of novel peak-picker techniques, such as deep-learning-based approaches and refinement of existing tools. MassDash is open-source under a BSD 3-Clause license and freely available at https//github.com/Roestlab/massdash, and a demo version can be accessed at https//massdash.streamlit.app.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Espectrometria de Massas
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Algoritmos
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Software
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Internet
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article