Effectiveness and chemical insights: Exploring interactions between nanomicelles and monoterpenoids for head lice treatment.
Pestic Biochem Physiol
; 201: 105886, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38685252
ABSTRACT
This study evaluates the pediculicidal activity of nanoformulations containing different binary essential oil component mixtures (eugenollinalool, 1,8 -cineolelinalool, and eugenolthymol) using immersion bioassays. These have allowed us to evaluate the knockdown time affecting 50% of the individuals (KT50). In addition, the type of interaction between the components in each mixture was established in terms of the combination index (IC). The KT50 values were 6.07; 8.83; 7.17 and 27.23 h for linalool, 1,8 -cineole, eugenol, and thymol, respectively. For the eugenollinalool mixtures, the efficacy was lower or equal to that obtained for the nanoformulations of the pure compounds, with values of KT50 about 13.33, 8.16 and 6.71 h for mixtures with ratios 31, 11 and 13, respectively. These mixtures present IC > 1, evidencing antagonistic interaction, which is enhanced with eugenol content. In the case of the binary mixtures of 1,8 -cineole linalool, KT50 values were similar to those obtained for eugenollinalool mixtures with similar ratios. In this case, IC assumes values close to unity, suggesting additive interactions independently of the mixture composition. On the other side, mixtures of eugenolthymol with 11 and 13 ratios showed values of 9.40 and 32.93 h, while the mixture with a 31 ratio showed the greatest effectiveness (KT50 of 4.42 h). Eugenolthymol mixtures show synergistic interaction (IC < 1) for combinations 31 and 11, while no interaction was observed for 13 combination. This indicates that eugenol enhances thymol activity. These results must be considered an important step forward to the development of effective pediculicidal nanoformulations based on botanical compounds.
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Base de dados:
MEDLINE
Assunto principal:
Eugenol
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Monoterpenos
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Eucaliptol
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Monoterpenos Acíclicos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article