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Effectiveness and chemical insights: Exploring interactions between nanomicelles and monoterpenoids for head lice treatment.
Toloza, Ariel C; Sosa-Quiroga, Eunice; Fañani, Agustina; Puente-Santamaria, Ana; Guzmán, Eduardo; Martínez, Emilia; Lucia, Alejandro.
Afiliação
  • Toloza AC; Centro de Investigaciones de Plagas e Insecticidas (UNIDEF, CONICET), J. Bautista de La Salle 4397, 1603 Villa Martelli, Buenos Aires, Argentina. Electronic address: atoloza@conicet.gov.ar.
  • Sosa-Quiroga E; Centro de Investigaciones de Plagas e Insecticidas (UNIDEF, CONICET), J. Bautista de La Salle 4397, 1603 Villa Martelli, Buenos Aires, Argentina.
  • Fañani A; Instituto de Ecología y Desarrollo Sustentable (INEDES, CONICET-UNLu), Ruta 5 y Avenida Constitución 6700, Luján, Buenos Aires, Argentina; Departamento de Ciencias Básicas, Universidad Nacional de Luján, Ruta 5 y Avenida Constitución - (6700), Luján, Buenos Aires, Argentina.
  • Puente-Santamaria A; Departamento de Química Física, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain.
  • Guzmán E; Departamento de Química Física, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain; Instituto Pluridisciplinar, Universidad Complutense de Madrid, Paseo Juan XXIII, Madrid, Spain.
  • Martínez E; Instituto de Ecología y Desarrollo Sustentable (INEDES, CONICET-UNLu), Ruta 5 y Avenida Constitución 6700, Luján, Buenos Aires, Argentina.
  • Lucia A; Instituto de Ecología y Desarrollo Sustentable (INEDES, CONICET-UNLu), Ruta 5 y Avenida Constitución 6700, Luján, Buenos Aires, Argentina.
Pestic Biochem Physiol ; 201: 105886, 2024 May.
Article em En | MEDLINE | ID: mdl-38685252
ABSTRACT
This study evaluates the pediculicidal activity of nanoformulations containing different binary essential oil component mixtures (eugenollinalool, 1,8 -cineolelinalool, and eugenolthymol) using immersion bioassays. These have allowed us to evaluate the knockdown time affecting 50% of the individuals (KT50). In addition, the type of interaction between the components in each mixture was established in terms of the combination index (IC). The KT50 values were 6.07; 8.83; 7.17 and 27.23 h for linalool, 1,8 -cineole, eugenol, and thymol, respectively. For the eugenollinalool mixtures, the efficacy was lower or equal to that obtained for the nanoformulations of the pure compounds, with values of KT50 about 13.33, 8.16 and 6.71 h for mixtures with ratios 31, 11 and 13, respectively. These mixtures present IC > 1, evidencing antagonistic interaction, which is enhanced with eugenol content. In the case of the binary mixtures of 1,8 -cineole linalool, KT50 values were similar to those obtained for eugenollinalool mixtures with similar ratios. In this case, IC assumes values close to unity, suggesting additive interactions independently of the mixture composition. On the other side, mixtures of eugenolthymol with 11 and 13 ratios showed values of 9.40 and 32.93 h, while the mixture with a 31 ratio showed the greatest effectiveness (KT50 of 4.42 h). Eugenolthymol mixtures show synergistic interaction (IC < 1) for combinations 31 and 11, while no interaction was observed for 13 combination. This indicates that eugenol enhances thymol activity. These results must be considered an important step forward to the development of effective pediculicidal nanoformulations based on botanical compounds.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Eugenol / Monoterpenos / Eucaliptol / Monoterpenos Acíclicos Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Eugenol / Monoterpenos / Eucaliptol / Monoterpenos Acíclicos Idioma: En Ano de publicação: 2024 Tipo de documento: Article