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Positive selection in the genomes of two Papua New Guinean populations at distinct altitude levels.
André, Mathilde; Brucato, Nicolas; Hudjasov, Georgi; Pankratov, Vasili; Yermakovich, Danat; Montinaro, Francesco; Kreevan, Rita; Kariwiga, Jason; Muke, John; Boland, Anne; Deleuze, Jean-François; Meyer, Vincent; Evans, Nicholas; Cox, Murray P; Leavesley, Matthew; Dannemann, Michael; Org, Tõnis; Metspalu, Mait; Mondal, Mayukh; Ricaut, François-Xavier.
Afiliação
  • André M; Estonian Biocentre, Institute of Genomics, University of Tartu, Riia 23b, 51010, Tartu, Tartumaa, Estonia.
  • Brucato N; Centre for Genomics, Evolution & Medicine, Institute of Genomics, University of Tartu, Riia 23b, 51010, Tartu, Tartumaa, Estonia.
  • Hudjasov G; Centre de Recherche sur la Biodiversité et l'Environnement (CRBE), Université de Toulouse, CNRS, IRD, Toulouse INP, Université Toulouse 3 - Paul Sabatier (UT3), Toulouse, France.
  • Pankratov V; Centre for Genomics, Evolution & Medicine, Institute of Genomics, University of Tartu, Riia 23b, 51010, Tartu, Tartumaa, Estonia.
  • Yermakovich D; Centre for Genomics, Evolution & Medicine, Institute of Genomics, University of Tartu, Riia 23b, 51010, Tartu, Tartumaa, Estonia.
  • Montinaro F; Centre for Genomics, Evolution & Medicine, Institute of Genomics, University of Tartu, Riia 23b, 51010, Tartu, Tartumaa, Estonia.
  • Kreevan R; Estonian Biocentre, Institute of Genomics, University of Tartu, Riia 23b, 51010, Tartu, Tartumaa, Estonia.
  • Kariwiga J; Department of Biosciences, Biotechnology and the Environment, University of Bari, Bari, Italy.
  • Muke J; Centre for Genomics, Evolution & Medicine, Institute of Genomics, University of Tartu, Riia 23b, 51010, Tartu, Tartumaa, Estonia.
  • Boland A; Strand of Anthropology, Sociology and Archaeology, School of Humanities and Social Sciences, University of Papua New Guinea, University 134, PO Box 320, National Capital District, Papua New Guinea.
  • Deleuze JF; School of Social Science, University of Queensland, St Lucia, QLD, Australia.
  • Meyer V; Social Research Institute Ltd, Port Moresby, Papua New Guinea.
  • Evans N; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), 91057, Evry, France.
  • Cox MP; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), 91057, Evry, France.
  • Leavesley M; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), 91057, Evry, France.
  • Dannemann M; ARC Centre of Excellence for the Dynamics of Language, Coombs Building, Fellows Road, CHL, CAP, Australian National University, Canberra, ACT, Australia.
  • Org T; School of Natural Sciences, Massey University, Palmerston North, New Zealand.
  • Metspalu M; Department of Statistics, University of Auckland, Auckland, New Zealand.
  • Mondal M; Strand of Anthropology, Sociology and Archaeology, School of Humanities and Social Sciences, University of Papua New Guinea, University 134, PO Box 320, National Capital District, Papua New Guinea.
  • Ricaut FX; College of Arts, Society and Education, James Cook University, P.O. Box 6811, Cairns, QLD, 4870, Australia.
Nat Commun ; 15(1): 3352, 2024 Apr 30.
Article em En | MEDLINE | ID: mdl-38688933
ABSTRACT
Highlanders and lowlanders of Papua New Guinea have faced distinct environmental stress, such as hypoxia and environment-specific pathogen exposure, respectively. In this study, we explored the top genomics regions and the candidate driver SNPs for selection in these two populations using newly sequenced whole-genomes of 54 highlanders and 74 lowlanders. We identified two candidate SNPs under selection - one in highlanders, associated with red blood cell traits and another in lowlanders, which is associated with white blood cell count - both potentially influencing the heart rate of Papua New Guineans in opposite directions. We also observed four candidate driver SNPs that exhibit linkage disequilibrium with an introgressed haplotype, highlighting the need to explore the possibility of adaptive introgression within these populations. This study reveals that the signatures of positive selection in highlanders and lowlanders of Papua New Guinea align closely with the challenges they face, which are specific to their environments.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Seleção Genética / Haplótipos / Desequilíbrio de Ligação / Polimorfismo de Nucleotídeo Único / Altitude Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Seleção Genética / Haplótipos / Desequilíbrio de Ligação / Polimorfismo de Nucleotídeo Único / Altitude Idioma: En Ano de publicação: 2024 Tipo de documento: Article