A General Molecular Structural Design for Highly Efficient Photopyroptosis that can be Activated within 10 s Irradiation.
Adv Mater
; 36(29): e2401145, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38692574
ABSTRACT
Photopyroptosis is an emerging research branch of photodynamic therapy (PDT), whereas there remains a lack of molecular structural principles to fabricate photosensitizers for triggering a highly efficient pyroptosis. Herein, a general and rational structural design principle to implement this hypothesis, is proposed. The principle relies on the clamping of cationic moieties (e.g., pyridinium, imidazolium) onto one photosensitive core to facilitate a considerable mitochondrial targeting (both of the inner and the outer membranes) of the molecules, thus maximizing the photogenerated reactive oxygen species (ROS) at the specific site to trigger the gasdermin E-mediated pyroptosis. Through this design, the pyroptotic trigger can be achieved in a minimum of 10 s of irradiation with a substantially low light dosage (0.4 J cmâ»2), compared to relevant work reported (up to 60 J cmâ»2). Moreover, immunotherapy with high tumor inhibition efficiency is realized by applying the synthetic molecules alone. This structural paradigm is valuable for deepening the understanding of PDT (especially the mitochondrial-targeted PDT) from the perspective of pyroptosis, toward the future development of the state-of-the-art form of PDT.
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Base de dados:
MEDLINE
Assunto principal:
Fotoquimioterapia
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Espécies Reativas de Oxigênio
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Fármacos Fotossensibilizantes
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Piroptose
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article