Cerebrospinal fluid reference proteins increase accuracy and interpretability of biomarkers for brain diseases.
Nat Commun
; 15(1): 3676, 2024 May 01.
Article
em En
| MEDLINE
| ID: mdl-38693142
ABSTRACT
Cerebrospinal fluid (CSF) biomarkers reflect brain pathophysiology and are used extensively in translational research as well as in clinical practice for diagnosis of neurological diseases, e.g., Alzheimer's disease (AD). However, CSF biomarker concentrations may be influenced by non-disease related inter-individual variability. Here we use a data-driven approach to demonstrate the existence of inter-individual variability in mean standardized CSF protein levels. We show that these non-disease related differences cause many commonly reported CSF biomarkers to be highly correlated, thereby producing misleading results if not accounted for. To adjust for this inter-individual variability, we identified and evaluated high-performing reference proteins which improved the diagnostic accuracy of key CSF AD biomarkers. Our reference protein method attenuates the risk for false positive findings, and improves the sensitivity and specificity of CSF biomarkers, with broad implications for both research and clinical practice.
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1
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
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Proteínas do Líquido Cefalorraquidiano
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Doença de Alzheimer
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article