An overview of the cholesterol metabolism and its proinflammatory role in the development of MASLD.
Hepatol Commun
; 8(5)2024 05 01.
Article
em En
| MEDLINE
| ID: mdl-38696365
ABSTRACT
Cholesterol is an essential lipid molecule in mammalian cells. It is not only involved in the formation of cell membranes but also serves as a raw material for the synthesis of bile acids, vitamin D, and steroid hormones. Additionally, it acts as a covalent modifier of proteins and plays a crucial role in numerous life processes. Generally, the metabolic processes of cholesterol absorption, synthesis, conversion, and efflux are strictly regulated. Excessive accumulation of cholesterol in the body is a risk factor for metabolic diseases such as cardiovascular disease, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease (MASLD). In this review, we first provide an overview of the discovery of cholesterol and the fundamental process of cholesterol metabolism. We then summarize the relationship between dietary cholesterol intake and the risk of developing MASLD, and also the animal models of MASLD specifically established with a cholesterol-containing diet. In the end, the role of cholesterol-induced inflammation in the initiation and development of MASLD is discussed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Colesterol na Dieta
/
Colesterol
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article