Nanocage-incorporated engineered destabilized 3'UTR ARE of ERBB2 inhibits tumor growth and liver and lung metastasis in EGFR T790M osimertinib- and trastuzumab-resistant and ERBB2-expressing NSCLC via the reduction of ERBB2.

Awah, Chidiebere U; Sun Mun, Joo; Paragodaarachchi, Aloka; Boylu, Baris; Nzegwu, Martin; Matsui, Hiroshi; Ogunwobi, Olorunseun

Awah, Chidiebere U; Sun Mun, Joo; Paragodaarachchi, Aloka; Boylu, Baris; Nzegwu, Martin; Matsui, Hiroshi; Ogunwobi, Olorunseun.

Afiliação

Awah CU; Department of Biological Sciences, Hunter College of The City University of New York, New York, NY, United States.
Sun Mun J; Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, United States.
Paragodaarachchi A; Department of Chemistry, Hunter College, City University of New York, New York, NY, United States.
Boylu B; Department of Chemistry, Hunter College, City University of New York, New York, NY, United States.
Nzegwu M; Ph.D. Program in Biochemistry, The Graduate Center of the City University of New York, New York, NY, United States.
Matsui H; Department of Biological Sciences, Hunter College of The City University of New York, New York, NY, United States.
Ogunwobi O; Department of Pathology, University of Tulane School of Medicine, New Orleans, LA, United States.

Front Oncol ; 14: 1344852, 2024.

Article em En | MEDLINE | ID: mdl-38699639

Palavras-chave

ERBB2/HER2; NSCLC EGFRT790M; engineered mRNA destabilization; iron oxide nanocages (IO); lung and liver metastasis inhibition; mRNA overwriting; nonsense mediated decay; osimertinib and trastuzumab resistance

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article