DDX21: The link between m<sup>6</sup>A and R-loops.

Lavergne, Guillaume; Roignant, Jean-Yves

DDX21: The link between m⁶A and R-loops.

Lavergne, Guillaume; Roignant, Jean-Yves.

Afiliação

Lavergne G; Center for Integrative Genomics, Génopode Building, Faculty of Biology and Medicine, University of Lausanne, CH-1015 Lausanne, Switzerland.
Roignant JY; Center for Integrative Genomics, Génopode Building, Faculty of Biology and Medicine, University of Lausanne, CH-1015 Lausanne, Switzerland; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg-University Mainz, Staudingerweg 5, 55128 Mainz, Germany. Electronic address: jean-yves.roignant@unil.ch.

Mol Cell ; 84(9): 1631-1632, 2024 May 02.

Article em En | MEDLINE | ID: mdl-38701738

ABSTRACT

ABSTRACT

In this issue of Molecular Cell, Hao et al.1 demonstrate that the RNA helicase DDX21 recruits the m6A methyltransferase complex to R-loops, ensuring proper transcription termination and genome stability.

Assuntos

RNA Helicases DEAD-box; RNA Helicases DEAD-box/metabolismo; RNA Helicases DEAD-box/genética; Humanos; Estruturas R-Loop; Metiltransferases/metabolismo; Metiltransferases/genética; Instabilidade Genômica; Adenosina/metabolismo; Adenosina/análogos & derivados; Terminação da Transcrição Genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Helicases DEAD-box Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Helicases DEAD-box Idioma: En Ano de publicação: 2024 Tipo de documento: Article