Sox9-coordinated cellular neighborhoods generate fibrosis.
Cell Stem Cell
; 31(5): 589-590, 2024 May 02.
Article
em En
| MEDLINE
| ID: mdl-38701754
ABSTRACT
Poorly regenerative organs deposit scar tissue to mend damage. Aggarwal et al. establish that transient Sox9 activity is necessary for early proximal tubule epithelial regeneration, while Trogisch et al. and Aggarwal et al. show that persistent Sox9 activity in epithelial and endothelial cells activates fibroblasts creating fibrotic microdomains in multiple organs.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fibrose
/
Fatores de Transcrição SOX9
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article