Zooplankton-based adverse outcome pathways: A tool for assessing endocrine disrupting compounds in aquatic environments.
Environ Res
; 252(Pt 3): 119045, 2024 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-38704014
ABSTRACT
Endocrine disrupting compounds (EDCs) pose a significant ecological risk, particularly in aquatic ecosystems. EDCs have become a focal point in ecotoxicology, and their identification and regulation have become a priority. Zooplankton have gained global recognition as bioindicators, benefiting from rigorous standardization and regulatory validation processes. This review aims to provide a comprehensive summary of zooplankton-based adverse outcome pathways (AOPs) with a focus on EDCs as toxicants and the utilisation of freshwater zooplankton as bioindicators in ecotoxicological assessments. This review presents case studies in which zooplankton have been used in the development of AOPs, emphasizing the identification of molecular initiating events (MIEs) and key events (KEs) specific to zooplankton exposed to EDCs. Zooplankton-based AOPs may become an important resource for understanding the intricate processes by which EDCs impair the endocrine system. Furthermore, the data sources, experimental approaches, advantages, and challenges associated with zooplankton-based AOPs are discussed. Zooplankton-based AOPs framework can provide vital tools for consolidating toxicological knowledge into a structured toxicity pathway of EDCs, offering a transformative platform for facilitating enhanced risk assessment and chemical regulation.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Poluentes Químicos da Água
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Zooplâncton
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Disruptores Endócrinos
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Rotas de Resultados Adversos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article