Rutin-loaded zein gel as a green biocompatible formulation for wound healing application.
Int J Biol Macromol
; 269(Pt 1): 132071, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38705334
ABSTRACT
Wound healing is a challenging clinical problem and efficient wound management is essential to prevent infection. This is best done by utilizing biocompatible materials in order to complete the healing in a rapid manner, with functional and esthetic outcomes. In this context, the zein protein fulfills the criteria of the ideal wound dressing which include non-toxicity and non-inflammatory stimulation. Zein gels containing rutin were prepared without any chemical refinement or addition of gelling agents in order to obtain a natural formulation characterized by antioxidant and anti-inflammatory properties to be proposed for the treatment of burns and sores. In vitro scratch assay showed that the proposed gel formulations promoted cell migration and a rapid gap closure within 24 h (~90 %). In addition, the in vivo activities of rutin-loaded zein gel showed a greater therapeutic efficacy in Wistar rats, with a decrease of the wound area of about 90 % at day 10 with respect to the free form of the bioactive and to DuoDERM®. The evaluation of various markers (TNF-α, IL-1ß, IL-6, IL-10) confirmed the anti-inflammatory effect of the proposed formulation. The results illustrate the feasibility of exploiting the peculiar features of rutin-loaded zein gels for wound-healing purposes.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Rutina
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Cicatrização
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Zeína
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Materiais Biocompatíveis
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Ratos Wistar
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Géis
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article