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Assessing protein and albumin recovery rates in different ascites filtration membrane washing methods for cell-free and concentrated ascites reinfusion therapy.
Yamada, Sachie; Nii, Norio; Ohashi, Atsushi; Hasegawa, Midori; Yuzawa, Yukio; Tsuboi, Naotake.
Afiliação
  • Yamada S; Department of Clinical Engineering, Fujita Health University Hospital, Toyoaka, Aichi, Japan.
  • Nii N; Department of Clinical Engineering, Fujita Health University Hospital, Toyoaka, Aichi, Japan.
  • Ohashi A; Faculty of Clinical Engineering, Fujita Health University, School of Medical Sciences, Toyoake, Aichi, Japan.
  • Hasegawa M; Department of Nephrology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
  • Yuzawa Y; Department of Nephrology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
  • Tsuboi N; Department of Nephrology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Fujita Med J ; 10(2): 53-59, 2024 May.
Article em En | MEDLINE | ID: mdl-38708077
ABSTRACT

Objectives:

In cell-free and concentrated ascites reinfusion therapy (CART), the protein recovery rate decreases when the filtration membrane gets clogged. Employing a device with a filtration membrane washing feature prevents clogging, but it leads to the loss of ascites within the filter, resulting in reduced protein recovery. This study employed a device with a membrane washing function to investigate the relationship between protein recovery rate and the quantity of washing solution used, depending on the selected washing method.

Methods:

We analyzed cases of CART conducted at Fujita Health University Hospital between May 2021 and November 2022. The cases were divided and compared between two groups one using flush and rinse as the washing method (flush+rinse group) and another using only flushing (flush group).

Results:

We identified nine cases and 16 sessions. In the flush+rinse group, the median amount of washing solution used per membrane washing was 259 mL per cycle, whereas it was 54 mL per cycle in the flush group. This difference was statistically significant (p<0.0001). The median total protein recovery rate was 53.8% for the flush+rinse group and 78.8% for the flush group, with the latter showing a significantly higher value (p=0.0199).

Conclusions:

In CART using a membrane washing function, adopting a washing method that reduces the amount of washing solution leads to an increase in the total protein recovery rate.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article