Design of Triazolium-Grafted Peptidomimetic Macrocycles with Facial Amphipathicity to Target Pathogenic Bacteria.
Org Lett
; 26(19): 4088-4092, 2024 May 17.
Article
em En
| MEDLINE
| ID: mdl-38709636
ABSTRACT
Access to 1,2,3-triazolium-grafted peptoid macrocycles was developed by macrocyclization and multivalent postmodification of linear peptoid oligomers carrying an alternance of benzylic and propargyl groups as side chains. X-ray analysis and NMR studies revealed a conformational preference for constrained hairpin-shaped structures leading to the facial amphipathic character of these macrocycles. A preliminary evaluation showed the antimicrobial activities of these new cationic amphipathic architectures.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Triazóis
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Testes de Sensibilidade Microbiana
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Compostos Macrocíclicos
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Peptidomiméticos
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Antibacterianos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article