[Earlier detection of lung cancer through analysis of circulating tumor DNA from blood]. / Tidigare upptäckt av lungcancer med analys av tumör-DNA i blod.
Lakartidningen
; 1212024 May 07.
Article
em Sv
| MEDLINE
| ID: mdl-38712636
ABSTRACT
To investigate the clinical use of analyzing circulating tumor DNA in a clinical setting we present a pilot study comprising 93 patients from individuals with suspected lung cancer. The study aimed to evaluate the capability of analyzing circulating tumor DNA at the initial medical visit in order to detect genetic changes and mutations associated with lung cancer in plasma samples. Tumor DNA from plasma was extracted and analyzed with Next Generation Sequencing (NGS) and the result was compared with a matched tumor tissue collected in close connection from the same individual. Cancer-associated genetic mutations could be confirmed in about 60 percent of the plasma samples, and we observed a higher degree of conformance in patients with a more advanced disease. The results from the study provide valuable insights for an early clinical use of analyzing circulating tumor DNA in cases of suspected lung cancer, which could contribute to improving early diagnosis and treatment strategies for patients with lung cancer.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Detecção Precoce de Câncer
/
DNA Tumoral Circulante
/
Neoplasias Pulmonares
/
Mutação
Idioma:
Sv
Ano de publicação:
2024
Tipo de documento:
Article