Substrate-controlled divergent remote C-H and N-H polyfluoroarylation of 2-aminopyrimidines with polyfluoroarenes via Pd(II)/Pd(0) catalysis.
Chem Commun (Camb)
; 60(43): 5630-5633, 2024 May 23.
Article
em En
| MEDLINE
| ID: mdl-38716516
ABSTRACT
Substrate-controlled product divergence in the reaction of 2-aminopyrimidines with polyfluoroarenes under palladium catalysis is demonstrated for the first time. The reaction of secondary N-alkylpyrimidine-2-amines with polyfluoroarenes leads to C5-H polyfluoroarylation via C-H/C-H coupling, while secondary N-aryl substituents yield N-H polyfluoroarylation, forming triarylamines.
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MEDLINE
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En
Ano de publicação:
2024
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Article