Diacylglycerol kinase alpha is a proliferation marker of intrahepatic cholangiocarcinoma associated with the prognosis.
Cancer Med
; 13(9): e7238, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38716625
ABSTRACT
BACKGROUND:
Intrahepatic cholangiocarcinoma (ICC) has a high recurrence rate and a poor prognosis. Thus, the development of effective treatment and prognostic biomarkers is required. High expression of diacylglycerol kinase alpha (DGKα) is a prognostic factor for the recurrence of hepatocellular carcinoma. However, the relationship between DGKα expression and prognosis in ICC has not been reported.METHODS:
Immunohistochemistry (IHC) with anti-DGKα antibody was performed on surgical specimens of ICC (n = 69). First, DGKα expression in cancer cells was qualitatively classified into four groups (-, 1+, 2+, 3+) and divided into two groups (DGKα- and DGKα+1 + to 3+). The relationship between clinical features and DGKα expression was analyzed. Second, Ki-67 expression was evaluated as a cell proliferation marker. The number of Ki-67-positive cells was counted, and the relationship with DGKα expression was examined.RESULTS:
DGKα IHC divided the patients into a DGKα+ group (1+ n = 15; 2+ n = 5; 3+ n = 5) and a DGKα- group (- n = 44). In the DGKα+ group, patients were older and had advanced disease. Both overall survival and recurrence-free survival (RFS) were significantly worse in the DGKα+ patients. DGKα+ was identified as an independent prognostic factor for RFS by multivariate analysis. Furthermore, the number of Ki-67-positive cells increased in association with the staining levels of DGKα.CONCLUSION:
Pathological DGKα expression in ICC was a cancer proliferation marker associated with recurrence. This suggests that DGKα may be a potential therapeutic target for ICC.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias dos Ductos Biliares
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Biomarcadores Tumorais
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Colangiocarcinoma
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Antígeno Ki-67
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Diacilglicerol Quinase
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Proliferação de Células
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article