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Per- and polyfluoroalkyl substances (PFAS) exposure in plasma and their blood-brain barrier transmission efficiency-A pilot study.
Xie, Meng-Yi; Lin, Zhi-Ying; Sun, Xiang-Fei; Feng, Jing-Jing; Mai, Lei; Wu, Chen-Chou; Huang, Guang-Long; Wang, Po; Liu, Ya-Wei; Liu, Liang-Ying; Zeng, Eddy Y.
Afiliação
  • Xie MY; Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 511443, China.
  • Lin ZY; Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, China.
  • Sun XF; Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 511443, China; Key Laboratory of Pollution Control and Ecosystem Restoration in Industry Clusters (Ministry of Education), School of Environment and Energy, South China University of Technology, Guangzhou 510
  • Feng JJ; Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin 541006, China.
  • Mai L; Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 511443, China; Subingtian Center for Speed Research and Training/Guangdong Key Laboratory of Speed-Capability Research, School of Physical Education, Jinan University, Guangzhou 510632, China.
  • Wu CC; Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 511443, China; Key Laboratory of Pollution Control and Ecosystem Restoration in Industry Clusters (Ministry of Education), School of Environment and Energy, South China University of Technology, Guangzhou 510
  • Huang GL; Department of Neurosurgery, Laboratory for Precision Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Nanfang Glioma Center, Guangzhou 510515, China.
  • Wang P; Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 511443, China.
  • Liu YW; Department of Neurosurgery, Laboratory for Precision Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
  • Liu LY; Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 511443, China.
  • Zeng EY; Key Laboratory of Pollution Control and Ecosystem Restoration in Industry Clusters (Ministry of Education), School of Environment and Energy, South China University of Technology, Guangzhou 510006, China. Electronic address: eddyzeng@scut.edu.cn.
Environ Int ; 187: 108719, 2024 May.
Article em En | MEDLINE | ID: mdl-38718677
ABSTRACT
Per- and polyfluoroalkyl substances (PFAS) have been shown to penetrate the blood-brain barrier (BBB) and accumulate in human brain. The BBB transmission and accumulation efficiency of PFAS, as well as the potential health risks from human co-exposure to legacy and emerging PFAS due to differences in transport efficiency, need to be further elucidated. In the present pilot study, 23 plasma samples from glioma patients were analyzed for 17 PFAS. The concentrations of PFAS in six paired brain tissue and plasma samples were used to calculate the BBB transmission efficiency of PFAS (RPFAS). This RPFAS analysis was conducted with utmost care and consideration amid the limited availability of valuable paired samples. The results indicated that low molecular weight PFAS, including short-chain and emerging PFAS, may have a greater potential for accumulation in brain tissue than long-chain PFAS. As an alternative to perfluorooctane sulfonic acid (PFOS), 62 chlorinated polyfluorinated ether sulfonate (62 Cl-PFESA) exhibited brain accumulation potential similar to that of PFOS, suggesting it may not be a suitable substitute concerning health risk in brain. The BBB transmission efficiencies of perfluorooctanoic acid, PFOS, and 62 Cl-PFESA showed similar trends with age, which may be an important factor influencing the entry of exogenous compounds into the brain. A favorable link between perfluorooctane sulfonamide (FOSA) and the development and/or progression of glioma may be implicated by a strong positive correlation (r2 = 0.94; p < 0.01) between RFOSA and Ki-67 (a molecular marker of glioma). However, a causal relationship between RFOSA and glioma incidence were not established in the present study. The present pilot study conducted the first examination of BBB transmission efficiency of PFAS from plasma to brain tissue and highlighted the importance of reducing and/or controlling exposure to PFAS.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Barreira Hematoencefálica / Fluorocarbonos Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Barreira Hematoencefálica / Fluorocarbonos Idioma: En Ano de publicação: 2024 Tipo de documento: Article