Predicting and Recognizing Drug-Induced Type I Brugada Pattern Using ECG-Based Deep Learning.
J Am Heart Assoc
; 13(10): e033148, 2024 May 21.
Article
em En
| MEDLINE
| ID: mdl-38726893
ABSTRACT
BACKGROUND:
Brugada syndrome (BrS) has been associated with sudden cardiac death in otherwise healthy subjects, and drug-induced BrS accounts for 55% to 70% of all patients with BrS. This study aims to develop a deep convolutional neural network and evaluate its performance in recognizing and predicting BrS diagnosis. METHODS ANDRESULTS:
Consecutive patients who underwent ajmaline testing for BrS following a standardized protocol were included. ECG tracings from baseline and during ajmaline were transformed using wavelet analysis and a deep convolutional neural network was separately trained to (1) recognize and (2) predict BrS type I pattern. The resultant networks are referred to as BrS-Net. A total of 1188 patients were included, of which 361 (30.3%) patients developed BrS type I pattern during ajmaline infusion. When trained and evaluated on ECG tracings during ajmaline, BrS-Net recognized a BrS type I pattern with an AUC-ROC of 0.945 (0.921-0.969) and an AUC-PR of 0.892 (0.815-0.939). When trained and evaluated on ECG tracings at baseline, BrS-Net predicted a BrS type I pattern during ajmaline with an AUC-ROC of 0.805 (0.845-0.736) and an AUC-PR of 0.605 (0.460-0.664).CONCLUSIONS:
BrS-Net, a deep convolutional neural network, can identify BrS type I pattern with high performance. BrS-Net can predict from baseline ECG the development of a BrS type I pattern after ajmaline with good performance in an unselected population.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Ajmalina
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Eletrocardiografia
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Síndrome de Brugada
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Aprendizado Profundo
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article