Y(OTf)3-Salazin-Catalyzed Asymmetric Aldol Condensation.
Molecules
; 29(9)2024 Apr 25.
Article
em En
| MEDLINE
| ID: mdl-38731454
ABSTRACT
The chiral aziridine-containing vicinal iminophenol tridentate ligands (named salazins) are a class of readily prepared chiral ligands from enantiopure aziridines and salicylaldehydes. Their scandium and yttrium triflate complexes show excellent reactivity and enantioselectivities in the catalytic asymmetric aldol condensation of electron-deficient aromatic aldehydes and ketones, including acetone and cycloalkanones. The stereoselectivity is rationalized to the strong π-stacking interaction between aromatic aldehydes and the vicinal iminophenol group in the chiral ligands.
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MEDLINE
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En
Ano de publicação:
2024
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Article