Anti-Obesity and Anti-Diabetic Effects of Ostericum koreanum (Ganghwal) Extract.
Int J Mol Sci
; 25(9)2024 Apr 30.
Article
em En
| MEDLINE
| ID: mdl-38732125
ABSTRACT
"Ganghwal" is a widely used herbal medicine in Republic of Korea, but it has not been reported as a treatment strategy for obesity and diabetes within adipocytes. In this study, we determined that Ostericum koreanum extract (OKE) exerts an anti-obesity effect by inhibiting adipogenesis and an anti-diabetic effect by increasing the expression of genes related to glucose uptake in adipocytes and inhibiting α-glucosidase activity. 3T3-L1 preadipocytes were differentiated for 8 days in methylisobutylxanthine, dexamethasone, and insulin medium, and the effect of OKE was confirmed by the addition of 50 and 100 µg/mL of OKE during the differentiation process. This resulted in a reduction in lipid accumulation and the expression of PPARγ (Peroxisome proliferator-activated receptor γ) and C/EBPα (CCAAT enhancer binding protein α). Significant activation of AMPK (AMP-activated protein kinase), increased expression of GLUT4 (Glucose Transporter Type 4), and inhibition of α-glucosidase activity were also observed. These findings provide the basis for the anti-obesity and anti-diabetic effects of OKE. In addition, OKE has a significant antioxidant effect. This study presents OKE as a potential natural product-derived material for the treatment of patients with metabolic diseases such as obesity- and obesity-induced diabetes.
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Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
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Adipócitos
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Fármacos Antiobesidade
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Células 3T3-L1
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PPAR gama
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Adipogenia
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Hipoglicemiantes
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article