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Lipidomics analysis of bone marrow in a mouse model of postmenopausal osteoporosis.
Zhong, Ziqing; Chen, Yongling; Ruan, Xuelian; Xie, Huilin; Wang, Binbin; Tan, Shaolin; Qin, Xue.
Afiliação
  • Zhong Z; Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
  • Chen Y; Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
  • Ruan X; Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
  • Xie H; Department of Orthopaedic Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510030, China.
  • Wang B; Department of Anesthesiology, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, China.
  • Tan S; Department of Orthopaedics, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, China. Electronic address: shaolintan@sr.gxmu.edu.cn.
  • Qin X; Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. Electronic address: qinxue@gxmu.edu.cn.
J Pharm Biomed Anal ; 246: 116212, 2024 Aug 15.
Article em En | MEDLINE | ID: mdl-38735209
ABSTRACT
Postmenopausal osteoporosis (PMOP) is a major public health problem worldwide, afflicting many postmenopausal women. Although many studies have focused on the biological role of individual lipids in osteoporosis, no studies have systematically elucidated the lipid profile of osteoporosis. In this study, liquid chromatography-tandem mass spectrometry (LC-MS/MS) technology based on multiple reaction monitoring (MRM) method was used to compare the levels of lipid molecules in bone marrow cells of osteoporotic mice (OVX) group and sham-operation (Sham) group. Principal component analysis (PCA) was used for multivariate statistics. Differential lipids were obtained by bar graph, heatmap and volcano map. A total of 400 lipid molecules were identified. A total of 199 lipid molecules were identified to be associated with PMOP, including 6 phospholipids and 3 sphingolipids. These differential lipid molecules provide a systematic lipid profile for osteoporosis, which helps to discover new candidate osteoporosis biomarkers, and their changes at the molecular level can be used as new targets for diagnosis or prevention.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoporose Pós-Menopausa / Modelos Animais de Doenças / Espectrometria de Massas em Tandem / Lipidômica / Lipídeos Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoporose Pós-Menopausa / Modelos Animais de Doenças / Espectrometria de Massas em Tandem / Lipidômica / Lipídeos Idioma: En Ano de publicação: 2024 Tipo de documento: Article